Advanced search×

Morphological Alterations in the Kidney of Rats with Natural and Experimental Leptospira Infection

M M Tucunduva de Faria, D A DA Athanazio, E A EA Gonçalves Ramos, E F EF Silva, M G MG Reis, and A I AI Ko

J Comp Pathol 137(4):8 (2007) PMID 17996544

Leptospirosis is a widespread anthropozoonosis, with a broad array of mammalian reservoirs, occurring as rural endemics, urban outbreaks related to floods, and emergent disease associated with water sports and recreational exposure in developed countries. Rats are the major source of human infection, particularly in urban areas; however few reports have focused on the pathology of leptospirosis in this host. This study reports pathological changes in 60 kidneys from captured wild rats and compares these with changes in the kidney of Wistar rats experimentally infected with Leptospira interrogans serovar Copenhageni strain FIOCRUZ L1-130. A broad range of morphological alterations were detected in the kidneys from captured rats but interstitial nephritis was the only feature reproduced under experimental conditions. The role of interstitial nephritis in the pathogenesis of leptospirosis is reviewed and it is suggested that rats may provide a potential tool for the study of colonization mechanisms and host resistance in acute leptospiral disease.

DOI: 10.1016/j.jcpa.2007.08.001
Version: za2963e q8za3 q8zb9 q8zc5 q8zde q8zec q8zfd q8zg8

Similar articles you may find interesting…

  1. High levels of serum mannose-binding lectin are associated with the severity of clinical signs of leptospirosis.
    K A Miranda, L R S Vasconcelos, ... P Moura

    Braz J Med Biol Res 42(4):353-7 (2009) PMID 19330263

    We determined the levels of serum MBL during leptospirosis infection. A double-antibody sandwich ELISA was used to detect the immunoreactive serum MBL. The ELISA plates were coated with monoclonal antibody to MBL and bound MBL or recombinant human MBL were detected by rabbit anti-human MBL serum. HR...
    PDF not found
  2. Decrease of plasma platelet-activating factor acetylhydrolase activity in lipopolysaccharide induced mongolian gerbil sepsis model.
    Junwei Yang, Jing Xu, ... Guoping Zhao

    PLoS One 5(2):e9190 (2010) PMID 20169191

    We demonstrated the in vivo effects of LPS upon the change of pPAF-AH activity in C57BL/6 mice and Mongolian gerbils. After LPS-treatment, the clinical manifestations of Mongolian gerbil model were apparently similar to that of C57BL/6 mouse sepsis model. The pPAF-AH activity increased in C57BL/6 mi...
    View PDF
  3. Leptospirosis: a worldwide resurgent zoonosis and important cause of acute renal failure and death in developing nations.
    Luzia S Cruz, Roberto Vargas, and Antonio Alberto Lopes

    Ethn Dis 19(1 Suppl 1):S1-37-41 (2009) PMID 19484873

    Leptospirosis, a spirochetal zoonosis, is a globally re-emerging infectious disease that has disseminated from its habitual rural base to become the cause of urban epidemics in poor communities of industrialized and developing nations. This review addresses the issues in the epidemiology, clinical f...