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The c@?myc Promoter: Still MysterY and Challenge

Inken Wierstra and Jürgen Alves

Adv Cancer Res (2008) PMID 18037408

The transcription factor c@?Myc is a key regulator of cell proliferation, cell growth, differentiation, and apoptosis. Deregulated c@?myc expression possesses a high transformation potential and the proto@?oncogene c@?myc represents a promising target in anticancer therapy. This review on the c@?myc promoter describes its organization, the different levels of its normal regulation (including initiation and elongation of transcription, the dual P1/P2 promoters, chromatin structure, c@?Myc autosuppression) as well as its deregulation in Burkitt's lymphoma. Furthermore, it summarizes the many different transcription factors, signal transduction pathways, and feedback loops that activate or repress c@?myc transcription. Finally, a concept for regulation of the c@?myc promoter in different biological settings, for example, immediate@?early induction, constant expression throughout the cell cycle in continuously cycling cells, repression during terminal differentiation and deregulation in cancer, is formulated.

DOI: 10.1016/S0065-230X(07)99004-1
Version: za2963e q8zaf q8zb6 q8zc8 q8zd2 q8zeb q8zf4 q8zg7

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