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Novel 2-(4-methylsulfonylphenyl)pyrimidine derivatives as highly potent and specific COX-2 inhibitors

Aurelio Orjales, Ramón Mosquera, Beatriz López, Roberto Olivera, Luis Labeaga, and M Teresa Núñez

Bioorg Med Chem 16(5):17 (2008) PMID 18158247

New series of pyrimidines I were synthesized and evaluated as cyclooxygenase-2 (COX-2) inhibitors. Compounds 8, 67, 69, 71, 82 and 83 were highly potent and specific COX-2 inhibitors (HWB COX-2 IC"5"0=2.4-0.3nM and 80- to 780-fold more selective than rofecoxib).

DOI: 10.1016/j.bmc.2007.11.079
Version: za2963e q8za4 q8zb0 q8zc1 q8zd9 q8ze9 q8zfb q8zg3
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