Advanced search×

U.S. budget 2009. A science budget of choices and chances.

Jeffrey J Mervis

Science 319(5864):714-5 (2008) PMID 18258869

DOI: 10.1126/science.319.5864.714
Version: za2963e q8za1 q8zb9 q8zc0 q8zda q8ze6 q8zf7 q8zg7

Similar articles you may find interesting…

  1. Dual Molecular Signals Mediate the Bacterial Response to Outer-Membrane Stress.
    Santiago Lima, Monica S Guo, and Robert T Sauer

    Science 340(6134):837-841 (2013) PMID 23687042

    We found that off-pathway intermediates in lipopolysaccharide transport and assembly provided an additional required signal. These distinct signals, arising from disruptions in the transport and assembly of the major outer-membrane components, jointly determined the rate of proteolytic destruction o...
  2. Dynamic vaccine blocks relapse to compulsive intake of heroin.
    Joel E Schlosburg, Leandro F Vendruscolo, and George F Koob

    Proc Natl Acad Sci U S A (2013) PMID 23650354

    We recently developed a "dynamic" vaccine that creates antibodies against heroin and its psychoactive metabolites by presenting multihaptenic structures to the immune system that match heroin's metabolism. The current study presents evidence of effective and continuous sequestration of brain-permeab...
  3. Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis.
    Christoph Anacker, Annamaria Cattaneo, and Carmine M Pariante

    Proc Natl Acad Sci U S A (2013) PMID 23650397

    We identify the glucocorticoid receptor (GR) target gene, serum- and glucocorticoid-inducible kinase 1 (SGK1), as one such mechanism. Using a human hippocampal progenitor cell line, we found that a small molecule inhibitor for SGK1, GSK650394, counteracted the cortisol-induced reduction in neurogene...