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Place du cancer parmi les facteurs de risque de la maladie thromboembolique veineuse

R Descourt, M Righini, M Carrier, and G Le Gal

Pathol Biol (Paris) 56(4):6 (2008) PMID 18325691

There is a strong association between cancer and venous thromboembolism (VTE). Cancer patients have a seven-fold higher risk of developing VTE as compared with noncancer patients. In the year following the diagnosis of cancer, 1.6% of patients will develop a VTE event. VTE is one of the main cause of death in cancer patients, accounting for about 15% of deaths. On the other hand, cancer patients represent 15 to 20% of all VTE cases. Beyond classical risk factors for VTE, specific risk factors are associated with VTE in cancer patients: tumor site, stage, histological type, treatment, duration of the disease. VTE occurrence is associated with a poorer outcome in cancer patients: a reduced survival is observed in cancer patients with VTE as compared to non-VTE cancer patients. This impact of VTE on prognosis varies according to cancer characteristics. Conversely, evolution of VTE is different in cancer patients, with a higher short-term risk of mortality and a higher risk of recurrences, including on anticoagulant treatment, also modulated by cancer characteristics.

Copyright © 2008 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.patbio.2007.12.008
Version: za2963e q8zab q8zbe q8zc2 q8zd7 q8ze7 q8zfc q8zga

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