Advanced search×

Intratumoral bleomycin and IL-12 electrochemogenetherapy for treating head and neck tumors in dogs.

Jeffry J Cutrera, Marina M Torrero, Keijiro K Shiomitsu, Neal N Mauldin, and Shulin S Li

Methods Mol Biol (2008) PMID 18370210

Bleomycin and Interleukin 12 have been used clinically to treat tumors; however, the co-administration of Bleomycin and Interleukin 12 followed by electroporation has not been tested clinically. In this study, dogs with spontaneous head and neck tumors were treated with one co-administration of Bleomycin and Interleukin 12 plasmid DNA followed by electroporation. The regression of the recurrent papillary tumor and the adjacent metastatic bone tumor was analyzed by multiple CT scans. The papillary tumor was completely eradicated in less than 2 weeks, and the bone tumor was not visible 23 weeks after the administration.

DOI: 10.1007/978-1-59745-194-9_24
Version: za2963e q8zae q8zb8 q8zcf q8zd2 q8ze9 q8zfe q8zgd

Similar articles you may find interesting…

  1. Developmental Expression of IL-12Rβ2 on Murine Naive Neonatal T Cells Counters the Upregulation of IL-13Rα1 on Primary Th1 Cells and Balance...
    Christine M Hoeman, Mermagya Dhakal, and Habib Zaghouani

    J Immunol (2013) PMID 23650613

    We show that by day 8 after birth, naive splenic T cells are no longer susceptible to IL-13Rα1 upregulation even when exposed to Ag within the neonatal environment. Furthermore, during the 8-d lapse, the naive splenic T cells spontaneously and progressively upregulate the IL-12Rβ2 chain, perhaps d...
  2. Human and mouse neuroinflammation markers in Niemann-Pick disease, type C1.
    Stephanie M Cologna, Celine V M Cluzeau, and Forbes D Porter

    J Inherit Metab Dis (2013) PMID 23653225

    We identified in the mouse model significant changes in expression of genes associated with inflammation and compared these results to the pattern of expression in human cortex and cerebellar tissue. From gene expression array analysis, complement 3 (C3) was increased in mouse and human post-mortem...
  3. Skeletal muscle interleukin-6 regulation in hyperthermia.
    Steven S Welc, Andrew R Judge, and Thomas L Clanton

    Am J Physiol Cell Physiol (2013) PMID 23636453

    We previously reported that IL-6 production is acutely elevated in skeletal muscles exposed to 41°C, but the regulatory pathways are poorly understood. This study characterizes the heat-induced transcriptional control of IL-6 in C2C12 muscle fibers. Hyperthermia exposure (42°C for 1 h) induced tra...