Advanced search×

Natural products, small molecules, and genetics in tuberculosis drug development.

Maria-Teresa MT Gutierrez-Lugo and Carole A CA Bewley

J Med Chem 51(9):2606-12 (2008) PMID 18393405

DOI: 10.1021/jm070719i
Version: za2963e q8za4 q8zb0 q8zca q8zd1 q8zed q8zf0 q8zge

Similar articles you may find interesting…

  1. The effect of nordihydroguaiaretic acid on iodoacetate-induced toxicity in cultured neurons.
    Noemí N Cárdenas-Rodríguez, Silvia S Guzmán-Beltrán, ... José J Pedraza-Chaverri

    Audio, Transactions of the IRE Profession... 23(2):137-42 (2009) PMID 19367647

    We evaluated the effect of this compound on the neurotoxicity induced by iodoacetate (IAA), an inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), on cerebellar granule neurons. In addition, as reactive oxygen species play an important role in IAA-induced cytotoxicity, we also studied the...
  2. Synthesis of natural product-inspired inhibitors of Mycobacterium tuberculosis mycothiol-associated enzymes: the first inhibitors of GlcNAc-...
    Belhu B BB Metaferia, Brandon J BJ Fetterolf, ... Carole A CA Bewley

    J Med Chem 50(25):6326-36 (2007) PMID 18020307

    Synthesis and evaluation of a chemical library of inhibitors of the mycothiol biosynthesis enzyme GlcNAc-Ins deacetylase (MshB) and the mycothiol-dependent detoxification enzyme mycothiol- S-conjugate amidase (MCA) from Mycobacterium tuberculosis are reported. The library was biased to include struc...
  3. Susceptibility and mode of binding of the Mycobacterium tuberculosis cysteinyl transferase mycothiol ligase to tRNA synthetase inhibitors.
    Maria-Teresa Gutierrez-Lugo and Carole A Bewley

    Bioorg Med Chem Lett 21(8):2480-3 (2011) PMID 21392992 PMCID PMC3109356

    We show that MshC is selectively inhibited by cysteinyl sulfamoyl adenosine, and that discrimination occurs at the amino acid moiety. Published by Elsevier Ltd....
    View PDF