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A pharmacokinetic study of etravirine (TMC125) co-administered with ranitidine and omeprazole in HIV-negative volunteers.

Monika M Schöller-Gyüre, Thomas N TN Kakuda, Goedele G De Smedt, Hilde H Vanaken, Marie-Paule MP Bouche, Monika M Peeters, Brian B Woodfall, and Richard M W RM Hoetelmans

Br J Clin Pharmacol 66(4):508-16 (2008) PMID 18492125

Etravirine is a next-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with activity against wild-type and NNRTI-resistant HIV. Proton pump inhibitors and H(2)-antagonists are frequently used in the HIV-negative-infected population, and drug-drug interactions have been described with other antiretrovirals. This study evaluated the effect of steady-state omeprazole and ranitidine on the pharmacokinetics of a single dose of etravirine.

DOI: 10.1111/j.1365-2125.2008.03214.x
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