## Lymphocytic hypophysitis occurring simultaneously with a functioning pituitary adenoma.

Lymphocytic Hypophysitis (LH) is a rare and previously under-recognised disorder, most commonly affecting young females in the post-partum period. It presents clinically with symptoms and signs related to either a pituitary mass or hypopituitarism, frequently mimicking a pituitary adenoma; the diagnosis of LH can only be made histologically with the presence of a dense lymphocytic infiltration usually confined to the anterior pituitary. We present two case histories of patients who presented with symptoms suggestive of a functioning pituitary adenoma who also had concomitant LH confirmed histologically. The first case was a 39 year old lady, with a history of primary hypothyroidism, who presented with weight gain and hirsutism and clinical and biochemical features of Cushing's syndrome. The second case was a 61 year old male, also with a history of primary hypothyroidism, who presented with visual field loss and biochemically with hyperprolactinaemia. In both patients, magnetic resonance (MR) imaging of the pituitary demonstrated an enlarged partially cystic pituitary mass with slight suprasellar extension. Both patients were treated surgically with transphenoidal drainage and excision and histological examination of the surgical specimens demonstrated a mixture of pathologies with fragments of adenohypophyseal tissue (staining positive for ACTH and prolactin respectively) with a dense chronic inflammatory cell infiltrate suggestive of LH in nearby normal anterior pituitary. In both cases a joint diagnosis of a functioning pituitary adenoma with LH was made. There have been only several reported cases of this combination of pathologies but LH even in isolation is becoming increasingly recognised.

Version: za2963e q8za1 q8zb0 q8zc3 q8zd2 q8zec q8zf6 q8zg4

#### Similar articles you may find interesting…

1. Continuous reversal of Hanle resonances of counter-propagating pulse and continuous-wave field

arXiv:1306.3944 [physics.optics] 17 Jun 2013

We study propagation dynamics of the two counter-propagating Lasers, the continuous-wave (CW) laser and the pulse of another laser, when Both lasers are tuned to the $F_{g}=2 \rightarrow F_{e}=1$ transition in $^{87}$Rb, and therefore can develop Hanle electromagnetically induced Transparency (EIT)...
2. Water loss from terrestrial planets with CO2-rich atmospheres

arXiv:1306.3266 [astro-ph.EP] 13 Jun 2013

We present a range of calculations we performed to Study the dependence of water loss rates from terrestrial planets on Atmospheric composition (CO2 and N2 levels), planetary mass, and external Parameters (stellar spectrum, orbital distance and impacts). From coupled 1D Climate and escape modeling,...
3. Experimental measurements of stress redistribution in flowing emulsions

arXiv:1306.0269 [cond-mat.soft] 3 Jun 2013

We study how local rearrangements alter droplet stresses within flowing dense Quasi-two-dimensional emulsions at area fractions $\phi \geq 0.88$. Using Microscopy, we measure droplet positions while simultaneously using their Deformed shape to measure droplet stresses. We find that rearrangements al...