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Rho-kinase inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contraction.

Motohiko Hanazaki, Masataka Yokoyama, Kiyoshi Morita, Atsushi Kohjitani, Hiroyasu Sakai, Yoshihiko Chiba, and Miwa Misawa

Anesth Analg 106(6):1765-71 (2008) PMID 18499607

Airway smooth muscle contraction is not caused by the increase in intracellular Ca(2+) ([Ca(2+)](i)) alone because agonist stimulation increases tension at the same [Ca(2+)](i) (increase in Ca(2+) sensitivity). The small G protein Rho A and Rho-kinase (ROCK) play important roles in the regulation of Ca(2+) sensitivity. In this study, we investigated the effects of three ROCK inhibitors (fasudil, Y-27632, and H-1152) on rat airway smooth muscle contraction and the effects of ROCK inhibitors on propofol-induced bronchodilatory effects.

References 23 articles

DOI: 10.1213/ane.0b013e31816f1fba
Version: za2963e q8za4 q8zbe q8zc7 q8zd0 q8ze3 q8zfa q8zgd

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