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Immunohistochemical study on liver fibrosis in biliary atresia.

Kiyoshi K Murata, Yoshimasa Y Kamata, Hirohumi H Munakata, Michihiro M Sugai, and Mutsuo M Sasaki

Hepatogastroenterology 55(81):179-83 (2008) PMID 18507102

Although advanced liver fibrosis is a critical complication in influencing the outcome of biliary atresia (BA), the mechanism is poorly understood. In adult hepatic disorders, the relationships between sinusoidal liver cells (SLC) such as hepatic stellate cells (HSCs), some growth factors and enzymes concerned with extracellular matrix (ECM) metabolism have been clarified, but are unknown in BA. This study aimed to investigate such relationships in BA.

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