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DETA/NONOate, a nitric oxide donor, produces antidepressant effects by promoting hippocampal neurogenesis.

Yao Y Hua, Xin-Yan XY Huang, Li L Zhou, Qi-Gang QG Zhou, Yao Y Hu, Chun-Xia CX Luo, Fei F Li, and Dong-Ya DY Zhu

Psychopharmacology (Berl) 200(2):231-42 (2008) PMID 18512047

Increasing evidence suggests that depression may be associated with a lack of hippocampal neurogenesis. Our recent study shows that endogenous nitric oxide (NO) contributes to chronic mild stress (CMS)-induced depression by suppressing hippocampal neurogenesis.

DOI: 10.1007/s00213-008-1200-1
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