The purpose of the present study was to evaluate the effect of ion pairing on the skin permeation of amlodipine. Amlodipine base (AM) was first prepared from amlodipine besilate (AM-B), then amlodipine adipate (AM-A), amlodipine oxalate (AM-O) and amlodipine maleate (AM-M) were prepared using AM and the corresponding organic acids. Differential scanning calorimetry (DSC) thermogram studies demonstrated the formation of complexes between AM and the various acids. In vitro percutaneous absorption of AM and its complexes was evaluated through excised rat skin using 2-chamber diffusion cells. The results showed that AM had the greatest steady-state flux and lowest permeability coefficient of the five compounds from the El system (ethanol:isopropyl myristate (IPM)= 2:8), and its four complexes all exhibited a lower flux and higher permeability coefficient than AM.
We calculate an analytical expression for the terrace-width distribution
$P(s)$ for an interacting step system with nearest and next nearest neighbor
Interactions. Our model is derived by mapping the step system onto a
Statistically equivalent 1D system of classical particles. The validity of the
A single graphene layer placed between two parallel Ni(111) surfaces screens
the strong attractive force and results in a significant reduction of adhesion
and sliding friction. When two graphene layers are inserted, each graphene is
attached to one of the metal surfaces with a significant binding...
The purpose of the present study was to design and evaluate a monolithic drug-in-adhesive patch with a novel pressure-sensitive adhesive (PSA) matrix based on styrene-isoprene-styrene (SIS) block copolymer. Testosterone was selected as the model drug. The orthogonal array design for...
Pubget Updates sends you emails when Pubget finds new papers that match your search. Use Pubget Updates to get the latest articles for your specialty, written by a colleague, or published by your favorite journals.