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Free Brick1 is a trimeric precursor in the assembly of a functional wave complex.

Emmanuel Derivery, Jenny Fink, Davy Martin, Anne Houdusse, Matthieu Piel, Theresia E Stradal, Daniel Louvard, and Alexis Gautreau

PLoS One 3(6):e2462 (2008) PMID 18560548 PMCID 2413427

The Wave complex activates the Arp2/3 complex, inducing actin polymerization in lamellipodia and membrane ruffles. The Wave complex is composed of five subunits, the smallest of which, Brick1/Hspc300 (Brk1), is the least characterized. We previously reported that, unlike the other subunits, Brk1 also exists as a free form.

DOI: 10.1371/journal.pone.0002462
Version: za2963e q8zaf q8zbc q8zcc q8zdd q8ze7 q8zf3 q8zg5
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