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Central tolerance to myogenic cell transplants does not include muscle neoantigens.

Geoffrey Camirand, Lionel Stéphan, Joël Rousseau, Mélanie K Sackett, Nicolas J Caron, Philippe Mills, Josef Kurtz, Megan Sykes, David M Rothstein, and Jacques P Tremblay

Transplantation 85(12):1791-801 (2008) PMID 18580473

Duchenne muscular dystrophy is a fatal genetic disease caused by lack of dystrophin. Myogenic cell transplantation (MT), a potential therapy for Duchenne muscular dystrophy, can restore dystrophin expression in muscles. Because allogeneic MT is highly resistant to peripheral tolerance, we proposed to induce central tolerance. However, given its immunogenicity, we asked whether central tolerance to donor major histocompatibility complex would allow long-term expression of dystrophin, a tissue-specific neoantigen in dystrophic recipients.

DOI: 10.1097/TP.0b013e31817726bc
Version: za2963e q8za3 q8zb9 q8zc0 q8zdb q8ze2 q8zf3 q8zgb

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