Advanced search×

Chromosomal translocations in cancer

Mridula M Nambiar, Vijayalakshmi V Kari, and Sathees C SC Raghavan

Biochimica et Biophysica Acta (BBA) - Revie... 1786(2):14 (2008) PMID 18718509

Genetic alterations in DNA can lead to cancer when it is present in proto-oncogenes, tumor suppressor genes, DNA repair genes etc. Examples of such alterations include deletions, inversions and chromosomal translocations. Among these rearrangements chromosomal translocations are considered as the primary cause for many cancers including lymphoma, leukemia and some solid tumors. Chromosomal translocations in certain cases can result either in the fusion of genes or in bringing genes close to enhancer or promoter elements, hence leading to their altered expression. Moreover, chromosomal translocations are used as diagnostic markers for cancer and its therapeutics. In the first part of this review, we summarize the well-studied chromosomal translocations in cancer. Although the mechanism of formation of most of these translocations is still unclear, in the second part we discuss the recent advances in this area of research.

Referenced by 1 articles

DOI: 10.1016/j.bbcan.2008.07.005
Version: za2963e q8za6 q8zb3 q8zc6 q8zdf q8ze0 q8zf4 q8zgd
Buy PDF

Similar articles you may find interesting…

  1. Existing and Emerging Technologies for Tumor Genomic Profiling.
    Laura E Macconaill

    J Clin Oncol (2013) PMID 23589546

    Ongoing global genome characterization efforts are revolutionizing our knowledge of cancer genomics and tumor biology. In parallel, information gleaned from these studies on driver cancer gene alterations-mutations, copy number alterations, translocations, and/or chromosomal rearrang...
    Buy PDF
  2. Fusion of the ZC3H7B and BCOR genes in endometrial stromal sarcomas carrying an X;22-translocation.
    Ioannis Panagopoulos, Jim Thorsen, and Francesca Micci

    Genes Chromosomes Cancer (2013) PMID 23580382

    We investigated two ESS characterized cytogenetically by the presence of a der(22)t(X;22)(p11;q13). Whole transcriptome sequencing one of the tumors identified a ZC3H7-BCOR chimeric transcript. Reverse transciptase-PCR with the ZC3H7B forward and BCOR reverse primer combinations confirmed the presen...
    Buy PDF
  3. Functional analysis of the two reciprocal fusion genes MLL-NEBL and NEBL-MLL reveal their oncogenic potential.
    Mariana M Emerenciano, Eric E Kowarz, and Rolf R Marschalek

    Cancer Lett 332(1):30-4 (2013) PMID 23340173

    We previously described the MLL-NEBL and NEBL-MLL genomic fusions in an infant AML patient with a chromosomal translocation t(10;11)(p12;q23). NEBL was the second Nebulin family member (LASP1, NEBL) which was found to be involved in MLL rearrangements. Here, we report on our attempts to unravel the...
    Buy PDF