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Could rusalatide acetate be the future drug of choice for diabetic foot ulcers and fracture repair?

Darrell H DH Carney and Barbara B Olszewska-Pazdrak

Expert Opin Pharmacother 9(15):2717-26 (2008) PMID 18803458

Rusalatide acetate (Chrysalin) is an investigational drug being evaluated for treatment of chronic wounds and fractures. Rusalatide acetate interacts with cell surface receptors to stimulate a cascade of cellular and molecular wound healing events, including activation of nitric oxide signaling. Rusalatide acetate significantly accelerated healing of diabetic foot ulcers and distal radius fractures in Phase I/II clinical trials. Subsequently, in one of the largest Phase III fracture studies to date, rusalatide acetate showed significant acceleration of distal radius fracture healing radiographically but failed to meet its primary clinical endpoint - time to removal of immobilization - within the intent-to-treat population. Subset analysis showed that rusalatide acetate met this primary clinical endpoint and significantly accelerated radiographic healing in osteopenic women. Rusalatide acetate may therefore show its greatest efficacy in healing-impaired patients.

DOI: 10.1517/14656566.9.15.2717
Version: za2963e q8za1 q8zbb q8zc5 q8zd7 q8ze6 q8zf9 q8zgb

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