Elucidation of the relationship between the structure and biological function of the glycosaminoglycans (GAGs) heparin and heparan sulfate (HS) presents an important analytical challenge mainly due to the difficulty in determining their fine structure. Heparin and HS are responsible for mediation of a wide range of biological actions through specific binding to a variety of proteins including those involved in blood coagulation, cell proliferation, differentiation and adhesion, and host-pathogen interactions. Therefore, there is a growing interest in characterizing the microstructure of heparin and HS and in elucidating the molecular level details of their interaction with peptides and proteins. This review discusses recent developments in the analytical methods used for sensitive separation, detection, and structural characterization of heparin and HS. A brief discussion of the analysis of contaminants in pharmaceutical heparin is also presented.
We theoretically study the phase sensitivity of the SU(1,1) interferometer
With a coherent light together with a squeezed vacuum input case using the
Method of homodyne. We find that the homodyne detection has better sensitivity
Than the intensity detection under this input case. For a certain inten...
We first show that it is NP-hard to check the conditions involving all
Submatrices of a given size.
This motivates us to investigate what classes of design matrices satisfy
These conditions. We demonstrate that the most general property, $\ell_q$
Sensitivity, holds with high probability for covari...
We engineered CHA be thermostable from 37 °C to 60 °C and in consequence have generalized its application to real-time detection of isothermal amplification reactions. CHA circuits were designed and optimized for both high and low temperature rolling circle amplification (RCA) and strand displacem...
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