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Hydrogen peroxide reduces lead-induced oxidative stress to mouse brain and liver.

Li

Bull Environ Contam Toxicol 82(4):419-22 (2009) PMID 18974911

Lead (Pb) intoxication may initiate many disorders in human and animals. This study investigates the role of exogenous hydrogen peroxide (H(2)O(2)) in inducing mouse tolerance to Pb exposure. Results showed that the simultaneous application of 1.2 microg H(2)O(2) per kg body weight efficiently protected mice against the Pb-caused injury, as revealed by decreased growth suppression caused by the Pb stress, increased antioxidative enzyme activity, reduced lipid peroxidation, and the protective effect on the nuclear DNA integrity. To our knowledge, this is the first finding of this sort.

DOI: 10.1007/s00128-008-9599-y
Version: za2963e q8za5 q8zb7 q8zcb q8zd2 q8ze4 q8zf6 q8zg2
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