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- This Paper
Two Supporting Factors Greatly Improve the Efficiency of Human iPSC Generation
Yang Zhao, Xiaolei Yin, Han Qin, Fangfang Zhu, Haisong Liu, Weifeng Yang, Qiang Zhang, Chengang Xiang, Pingping Hou, Zhihua Song, Yanxia Liu, Jun Yong, Pengbo Zhang, Jun Cai, Meng Liu, Honggang Li, Yanqin Li, Xiuxia Qu, Kai Cui, Weiqi Zhang, Tingting Xiang, Yetao Wu, Yiding Zhao, Chun Liu, Chen Yu, Kehu Yuan, Jinning Lou, Mingxiao Ding and Hongkui Deng
Cell Stem Cell 3(5):475-9 (2008)
PMID 18983962
Human fibroblasts can be induced into pluripotent stem cells (iPSCs), but the reprogramming efficiency is quite low. Here, we screened a panel of candidate factors in the presence of OCT4, SOX2, KLF4, and c-MYC in an effort to improve the reprogramming efficiency from human adult fibroblasts. We found that p53 siRNA and UTF1 enhanced the efficiency of iPSC generation up to 100-fold, even when the oncogene c-MYC was removed from the combinations.
DOI: 10.1016/j.stem.2008.10.002
Version: za2963e q8za6 q8zbf q8zcf q8zd8 q8zed q8zfd q8zg0
DOI: 10.1016/j.stem.2008.10.002
Version: za2963e q8za6 q8zbf q8zcf q8zd8 q8zed q8zfd q8zg0