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Predicting DNA recognition by Cys2His2 zinc finger proteins.

Anton V AV Persikov, Robert R Osada, and Mona M Singh

Bioinformatics 25(1):22-9 (2009) PMID 19008249

Cys(2)His(2) zinc finger (ZF) proteins represent the largest class of eukaryotic transcription factors. Their modular structure and well-conserved protein-DNA interface allow the development of computational approaches for predicting their DNA-binding preferences even when no binding sites are known for a particular protein. The 'canonical model' for ZF protein-DNA interaction consists of only four amino acid nucleotide contacts per zinc finger domain.

DOI: 10.1093/bioinformatics/btn580
Version: za2963e q8za6 q8zb5 q8zc7 q8zd8 q8zea q8zf2 q8zg0

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