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Activation of a Nodal-independent signaling pathway by Cripto-1 mutants with impaired activation of a Nodal-dependent signaling pathway

Caterina C Bianco, Margaret M Mysliwiec, Kazuhide K Watanabe, Mario M Mancino, Tadahiro T Nagaoka, Monica M Gonzales, and David S DS Salomon

FEBS Lett 582(29):6 (2008) PMID 19013461

Cripto-1, a co-receptor for Nodal, can activate Nodal-dependent and Nodal-independent signaling pathways. In this study we have investigated whether Cripto-1 mutants, that fail to activate a Nodal-dependent signaling pathway, are capable to activate a Nodal-independent signaling pathway in mammary epithelial cells. Cripto-1 mutants expressed in EpH4 mouse mammary epithelial cells are fully functional in regard to activation of a Nodal-independent signaling pathway, leading to phosphorylation of mitogen-activated protein kinase (MAPK) and Akt and to enhanced proliferation and motility of these cells, suggesting that Cripto-1 mutants with impaired Nodal signaling are still active in a Nodal-independent signaling pathway. Structured summary: MINT-6797299: Glypican 1 (uniprotkb:P35052) physically interacts (MI:0218) with Cr 1 (uniprotkb:P13385) by anti bait coimmunoprecipitation (MI:0006)

DOI: 10.1016/j.febslet.2008.10.052
Version: za2963e q8za4 q8zb4 q8zcb q8zd0 q8ze4 q8zfb q8zga

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