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Nickel-catalyzed decarbonylative addition of anhydrides to alkynes.

Yuichi Kajita, Takuya Kurahashi, and Seijiro Matsubara

J Am Chem Soc 130(51):17226-7 (2008) PMID 19049285

An intermolecular nickel-catalyzed addition reaction has been developed where phthalic anhydrides react with alkynes to afford substituted isocoumarins. A mechanistic rationale is proposed, implying reductive elimination of Ni(0) promoted by ZnCl(2) cocatalyst as the key step of the catalytic cycle.

DOI: 10.1021/ja806569h
Version: za2963e q8za5 q8zb0 q8zc0 q8zd7 q8ze7 q8zf7 q8zg7

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