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The utility of 6-month protocol renal biopsy under modern immunosuppression.

A A Yango, R R Gohh, L J LJ Wang, P P Morrissey, M M Shih, K K Lowery, K K Charpentier, A A Gautam, C C Mendonca, S S Kumar, L L Dworkin, and A A Monaco

Clin Nephrol 70(6):490-5 (2008) PMID 19049705

Protocol biopsies after renal transplantation are useful in detecting subclinical rejection. In earlier studies, the incidence of subclinical rejection was high among renal transplant recipients on a cyclosporine-based immunosuppression. However, recent data show that subclinical rejection is low under tacrolimus-based immunosuppression. This study evaluates the utility of 6-month protocol biopsy in renal transplant recipients under induction with rabbit antithymocyte globulin and maintenance immunosuppression with tacrolimus, mycophenolate mofetil (MMF) and corticosteroids.

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