[Urogenital pathology in patients with chronic obstructive lung disease and ischemic heart disease].

Klin Med (Mosk) 86(10):23-8 (2008) PMID 19069454

The objective of this study was to elucidate the incidence and clinical features of renal dysfunction and urogenital system disorders in 956 patients with chronic obstructive lung disease (COLD) and/or coronary heart disease (CHD). COLD was diagnosed in 346 patients (group 1), COLD and CHD in 402 (group 2), CHD in 211 (group 3). The methods included X-ray studies (survey and excretory urography), functional diagnostics (ECG, Doppler cardiography, assessment of external respiration, abdominal, renal, and bladder ultrasound, measurements of residual urine, transrectal and transabdominal examination of prostate). The glomerular filtration rate was estimated using Cockcrofft-Gault and MDRD formulas and Rerberg- Tareev method, renal hemodynamics by duplex scanning of renal arteries. Inflammatory urogenital diseases were most frequently diagnosed in group 2 (chronic cystitis 83.8%, chronic pyelonephritis 73.9%). Diabetic nephropathy common in this group (25.4%) was related to the high prevalence of diabetes mellitus in these patients (37.8%) compared with 26.3 and 29.9% in groups 1 and 3 respectively. Ischemic renal disease occurred in every tenth patient of group 2 or much more frequently than in groups 1 and 3. This suggests additive COLD and CHD effect on the atherosclerotic process. The combination of these diseases was responsible for a large fraction of patients with chronic renal insufficiency in group 2 (45%). It is concluded that concomitant urogenital pathology in patients with COLD results in mutual aggravation of the clinical course of the two diseases and requires additional examination and obligatory medicamentous correction.