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Effect of elevated PEEP on dynamic variables of fluid responsiveness in a pediatric animal model.

Audio, Transactions of the IRE Professional Gro... 18(12):1170 (2008) PMID 19076570

Previous studies have demonstrated that stroke volume variation (SVV), pulse pressure variation (PPV) and global end-diastolic volume (GEDV) can be used to predict the response to fluid administration. Currently, little information is available whether application of different levels of positive end-expiratory pressure (PEEP), especially in infants and neonates, affects their ability to predict fluid responsiveness. The aim of our study was to assess the effect of increasing PEEP levels on the predictive value of SVV, PPV and GEDV with respect to fluid responsiveness.

DOI: 10.1111/j.1460-9592.2008.02770.x