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Imaging the penumbra - strategies to detect tissue at risk after ischemic stroke

M M Ebinger, D A DA De Silva, S S Christensen, M W MW Parsons, R R Markus, G A GA Donnan, and S M SM Davis

J Clin Neurosci 16(2):10 (2009) PMID 19097909

The aim of thrombolytic therapy after acute ischemic stroke is salvage of the ischemic penumbra. Several imaging techniques have been used to identify the penumbra in patients who may benefit from reperfusion beyond the currently narrow 3-hour time-window for thrombolysis. We discuss the advantages and disadvantages of positron emission tomography (PET), single photon emission computed tomography (SPECT), MRI and CT scans. We comment on concepts of clinical-imaging mismatch models and we explore the implications for clinical trials.

Copyright © 2009 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.jocn.2008.04.002
Version: za2963e q8zab q8zb1 q8zc1 q8zd9 q8ze4 q8zf3 q8zgc
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