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Effects of cytochrome P450 inducers and inhibitors on the pharmacokinetics of intravenous furosemide in rats: involvement of CYP2C11, 2E1, 3A1 and 3A2 in furosemide metabolism.

Kyung H KH Yang, Young H YH Choi, Unji U Lee, Joo H JH Lee, and Myung G MG Lee

J Pharm Pharmacol 61(1):47-54 (2009) PMID 19126296

It has been reported that the non-renal clearance of furosemide was significantly faster in rats pretreated with phenobarbital but was not altered in rats pretreated with 3-methylcholanthrene. However, no studies on other cytochrome P450 (CYP) isozymes have yet been reported in rats.

DOI: 10.1211/jpp/61.01.0007
Version: za2963e q8zaa q8zbc q8zc4 q8zd5 q8zeb q8zf3 q8zg8
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