Demonstration of immunologic memory using serogroup C meningococcal glycoconjugate vaccine.

Pediatr Infect Dis J 28(2):92-7 (2009) PMID 19131903

Studies of glycoconjugate vaccines have traditionally used an immune challenge with a plain polysaccharide vaccine to demonstrate immunologic memory. Plain polysaccharide vaccines are poorly immunogenic in children and can induce subsequent immunologic hyporesponsiveness. We therefore assessed the use of glycoconjugate vaccines as an alternative method of demonstrating immunologic memory.