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A female survivor of childhood medulloblastoma presenting with growth-hormone-induced edema and inflammatory lesions: a case report.

Veronica V Biassoni, Federica F Pallotti, Filippo F Spreafico, Ettore E Seregni, Lorenza L Gandola, Antonella A Martinetti, Emilio E Bombardieri, and Maura M Massimino

J Med Case Rep (2009) PMID 19149892 PMCID 2633270

The improved survival of children with brain tumors has increased concerns about treatment-related sequelae. Growth hormone deficiency is frequently observed after craniospinal irradiation for medulloblastoma. It has been widely reported that growth hormone replacement therapy does not increase the risk of second tumors, but there are reports in the literature of growth hormone, and its downstream mediator insulin-like Growth Factor 1, having an important proinflammatory action. There are few reports, however, on the "in-vivo" induction of edema and symptomatic inflammatory lesions during replacement therapy.

DOI: 10.1186/1752-1947-3-17
Version: za2963e q8za2 q8zb6 q8zc3 q8zd8 q8zee q8zff q8zga
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