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Strontium fructose 1,6-diphosphate alleviates early diabetic testopathy by suppressing abnormal testicular matrix metalloproteinase system in streptozocin-treated rats.

Qi Q Zhang, Hao-Ran HR Liu, Han-Jie HJ Ying, De-Zai DZ Dai, Xiao-Yun XY Tang, and Yin Y Dai

J Pharm Pharmacol 61(2):229-36 (2009) PMID 19178771

Male hypogonadism is frequently associated with testopathy in patients with type 2 diabetes and in middle-aged males. We hypothesized that abnormal matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in testis have large roles to play in male hypogonadism. It has been found in diabetic rats that a novel compound, strontium fructose 1,6-diphosphate (FDP-Sr), with extra high energy supply, could reverse male hypogonadism by normalizing MMP-9 and TIMPs in the testis. We investigated whether FDP-Sr could be promising in treating diabetic testopathy.

DOI: 10.1211/jpp/61.02.0013
Version: za2963e q8za8 q8zb4 q8zcb q8zdc q8ze4 q8zf9 q8zg1
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