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Effect of moderate hepatic insufficiency on the pharmacokinetics of sitagliptin.

Elizabeth M EM Migoya, Catherine H CH Stevens, Arthur J AJ Bergman, Wen-lin WL Luo, Kenneth C KC Lasseter, Stacy C SC Dilzer, Michael J MJ Davies, John A JA Wagner, and Gary A GA Herman

Can J Clin Pharmacol 16(1):e165-70 (2009) PMID 19221403

Sitagliptin is a highly selective dipeptidyl peptidase-4 inhibitor for the treatment of patients with type 2 diabetes. Sitagliptin is primarily excreted by renal elimination as unchanged drug, with only a small percentage (approximately 16%) undergoing hepatic metabolism.

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