Advanced search×

Polymorphisms of the scavenger receptor class B member 1 are associated with insulin resistance with evidence of gene by sex interaction.

Jeanette J JJ McCarthy, Aleefia A Somji, Lauren A LA Weiss, Brian B Steffy, Raquel R Vega, Elizabeth E Barrett-Connor, Gregory G Talavera, and Richard R Glynne

J Clin Endocrinol Metab 94(5):1789-96 (2009) PMID 19276229

Genetic variation in diabetes-associated genes cumulatively explain little of the overall heritability of this trait. We sought to determine whether polymorphisms of the scavenger receptor class B, member I (SCARB1), an estrogen-regulated chromosome 12q24 positional candidate diabetes gene, were associated with type 2 diabetes or insulin resistance in a sex-specific fashion.

DOI: 10.1210/jc.2008-2800
Version: za2963e q8za3 q8zbb q8zc0 q8zd0 q8zed q8zff q8zgd
Buy PDF

Similar articles you may find interesting…

  1. Determination of the high prevalence of Dual/Mixed- or X4-tropism among HIV-1 CRF01_AE in Hong Kong by genotyping and phenotyping methods.
    Sabrina Wai-Chi To, Jonathan Hk Chen, and Wc Yam

    AIDS Res Hum Retroviruses (2013) PMID 23647565

    Our phenotypic data proposed a better genotypic tropism prediction for HIV-1 CRF01_AE would be using both Geno2pheno (FPR = 10%, Clonal) and WebPSSM (x4r5 subtype B matrix) algorithms in combination. The sensitivity and specificity for this combination was 88.9% and 89.3% respectively. The comparati...
    Buy PDF
  2. Novel ferrocenyl derivatives exert anti-cancer effect in human lung cancer cells in vitro via inducing G1-phase arrest and senescence.
    Ying Li, Han-Lin Ma, and Jun-Ying Miao

    Acta Pharmacol Sin (2013) PMID 23645009

    Compounds 5b, 5d, and 5e (40 and 80 μmol/L) caused significant decrease of A549 cell viability, while other 4 compounds had no effect on the cells. Compounds 5b, 5d, and 5e (80 μmol/L) induced G1-phase arrest (increased the G1 population by 22.6%, 24.23%, and 26.53%, respectively), and markedly inc...
    Buy PDF
  3. A novel c.-274C>G polymorphism in bovine SIRT1 gene contributes to diminished promoter activity and is associated with increased body size.
    Ming-Xun Li, Xiao-Mei Sun, and Hong Chen

    Anim Genet (2013) PMID 23647079

    We screened and identified a novel polymorphism (c.-274C>G) in the SIRT1 promoter region. In silico prediction reveals that this SNP is in the core of cell cycle-dependent element (CDE)-binding motif. Interestingly, the G allele abolished a CDE-binding site, which suggested its functional significan...
    Buy PDF