[The influence of mexidol on post-radiation recovery of hemopoietic system]

Radiats Biol Radioecol 49(1):90-6 (2009) PMID 19368329

The purpose of this work was the study in experiments on mice of influence of mexidol on current and outcome of an acute radiation sickness. At an irradiation in a dose 6.0 Gy was studied a condition of hemopoietic system, and at an irradiation in a dose 7.7 Gy a survival rate of animals. In all experiments mexidol applied in two circuits of introduction. The first circuit - once per day with 1 for 8 day after the irradiation. The second circuit of introduction: with 1 for 5 day--two times per day and on 6-8 day once per day. The introduction of mexidol after influence of ionizing radiation reduces a degree of radiative defeat of bone marrow and promotes the activization post-radiation recovery of an erythropoiesis, neutrophilopoiesis in an bone marrow and lymphopoiesis in a thymus gland. This effect is more expressed at introduction mexidol two times per day. At influence of ionizing radiation in a dose 7.7 Gy has survived 56% of mice. The introduction of mexidol two times per day was enlarged by survival rate animal up to 94%. The application of mexidol once per day essentially did not influence on the survival rate of the irradiated mice. The received data show, that the introduction of mexidol with 1 for 8 day after an irradiation, frameing a favorable metabolic background, stimulates recovery processes in hemopoietic system, reduces gravity of a acute radiation sickness and by that enlarges the survival rate of the irradiated animals.