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Sustained release of microbicides by newly engineered vaginal rings.

Brij B BB Saxena, Young A YA Han, Dingyi D Fu, Premila P Rathnam, Mukul M Singh, Jeffrey J Laurence, and Sidney S Lerner

AIDS 23(8):917-22 (2009) PMID 19381077

An effective vaginal microbicide against sexual HIV transmission remains elusive, with requirements for adherence to appropriate application of effective, nontoxic products being a major deterrent. We explored methods to enable sustained release of combinations of antiretroviral microbicides, utilizing intravaginal rings composed of biosoluble Acacia gum or nonbiodegradable hydrogel of 2-hydroxyethyl methacrylate and sodium methacrylate, materials approved for use by the US Food and Drug Administration.

DOI: 10.1097/QAD.0b013e32832af57c
Version: za2963e q8zab q8zb1 q8zce q8zda q8ze8 q8zf7 q8zg5
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