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Complex discovery from weighted PPI networks.

Guimei G Liu, Limsoon L Wong, and Hon Nian HN Chua

Bioinformatics 25(15):1891-7 (2009) PMID 19435747

Protein complexes are important for understanding principles of cellular organization and function. High-throughput experimental techniques have produced a large amount of protein interactions, which makes it possible to predict protein complexes from protein-protein interaction (PPI) networks. However, protein interaction data produced by high-throughput experiments are often associated with high false positive and false negative rates, which makes it difficult to predict complexes accurately.

DOI: 10.1093/bioinformatics/btp311
Version: za2963e q8zac q8zb3 q8zc3 q8zd9 q8zef q8zf5 q8zg8

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