Exploring functional beta-cell heterogeneity in vivo using PSA-NCAM as a specific marker.
Melis M Karaca,
Julien J Castel,
Cécile C Tourrel-Cuzin,
Manuel M Brun,
Anne A Géant,
Mathilde M Dubois,
Sandra S Catesson,
Marianne M Rodriguez,
Serge S Luquet,
Pierre P Cattan,
Brian B Lockhart,
Jochen J Lang,
Alain A Ktorza,
Christophe C Magnan and
Catherine C Kargar
crossref 4(5):e5555 1 Jan 2009
PMID 19440374
The mass of pancreatic beta-cells varies according to increases in insulin demand. It is hypothesized that functionally heterogeneous beta-cell subpopulations take part in this process. Here we characterized two functionally distinct groups of beta-cells and investigated their physiological relevance in increased insulin demand conditions in rats.
DOI: 10.1371/journal.pone.0005555
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