The neurotoxic peptide A@b^4^2 is derived from the amyloid precursor protein by proteolytic cleavage and is deposited in the brain of patients suffering from Alzheimer's disease (AD). In this study we generate a high affinity monoclonal antibody that targets the C-terminal end of A@b^4^2 with high specificity. By this is meant that the paratope of the antibody must enclose the C-terminal end of A@b^4^2 including the carboxy-group of amino acid 42, and not just recognize a linear epitope in the C-terminal part of A@b. This has been accomplished by using a unique antigen construct made by the Ligand Presenting Assembly technology (LPA technology). This strategy results in dimeric presentation of the free C-terminal end of A@b^4^2. The generated Mab A@b1.1 is indeed specific for the C-terminal end of A@b^4^2 to which it binds with high affinity. Mab A@b1.1 recognizes the epitope in human AD tissue and stains plaques with high specificity. Therefore the monoclonal antibody can thus be useful in the histological investigations of the AD pathology.
We study the properties of correlated MIMO
Multiple-access channels in the presence of external interference. Using the
Replica method from statistical physics, we derive the ergodic sum-rate of the
Communication for arbitrary signal constellations when the numbers of antennas
At both ends of the ch...
We present a functional programming language for specifying constraints over
Tree-shaped data. The language allows for Haskell-like algebraic data types and
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Satisfiability problems in propositional logic. We present an appl...
We explore an approach for studying epistasis
In humans using a Drosophila melanogaster model of neonatal diabetes mellitus.
Expression of mutant preproinsulin, hINSC96Y, in the eye imaginal disc mimics
The human disease activating conserved cell stress response pathways leading to
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