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A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease.

C C Keywood, M M Wakefield, and J J Tack

Gut 58(9):1192-9 (2009) PMID 19460767

In preclinical models, antagonism of metabotropic glutamate receptor 5 (mGluR5) reduces transient lower oesophageal sphincter relaxations (TLOSRs) and increases LOS pressure. This study evaluated the effect of ADX10059, a potent, selective, negative allosteric modulator of mGluR5, on oesophageal pH-metry and clinical symptoms in GORD.

DOI: 10.1136/gut.2008.162040
Version: za2963e q8za0 q8zba q8zcf q8zdc q8zec q8zfa q8zge
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