Advanced search×

Diminished global arginine bioavailability and increased arginine catabolism as metabolic profile of increased cardiovascular risk.

W H Wilson WH Tang, Zeneng Z Wang, Leslie L Cho, Danielle M DM Brennan, and Stanley L SL Hazen

J Am Coll Cardiol 53(22):2061-7 (2009) PMID 19477356

We hypothesized that an integrated assessment of arginine with its catabolic products might better predict cardiovascular risks than arginine levels alone.

Copyright © 2009 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.jacc.2009.02.036
Version: za2963e q8za7 q8zbb q8zc2 q8zd7 q8zea q8zf7 q8zg2
Buy PDF

Similar articles you may find interesting…

  1. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Zeneng Wang, Elizabeth Klipfell, ... Stanley L Hazen

    Nature 472(7341):57-63 (2011) PMID 21475195 PMCID PMC3086762

    We used a metabolomics approach to generate unbiased small-molecule metabolic profiles in plasma that predict risk for CVD. Three metabolites of the dietary lipid phosphatidylcholine--choline, trimethylamine N-oxide (TMAO) and betaine--were identified and then shown to predict risk for CVD in an ind...
    View PDF
  2. Alternative mutations of a positively selected residue elicit gain or loss of functionalities in enzyme evolution.
    Malena A Norrgård, Ylva Ivarsson, ... Bengt Mannervik

    Proc Natl Acad Sci U S A 103(13):4876-81 (2006) PMID 16549767 PMCID 1458763

    We show, by saturation mutagenesis, that mutations of a hypervariable residue in human glutathione transferase M2-2 can differentially change the enzyme's substrate-activity profile with alternative substrates and, furthermore, enable or disable dissimilar chemical reactions. Crystal structures demo...
    View PDF
  3. Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element...
    Tiangang T Li, Xiaoying X Kong, ... John Y L JY Chiang

    J Biol Chem 281(39):28745-54 (2006) PMID 16885156 PMCID 1576296

    We conclude that insulin has dual effects on human CYP7A1 gene transcription; physiological concentrations of insulin rapidly inhibit FoxO1 activity leading to stimulation of the human CYP7A1 gene, whereas prolonged insulin treatment induces SREBP-1c, which inhibits human CYP7A1 gene transcription....
    View PDF