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The lactotripeptides isoleucine-proline-proline and valine-proline-proline do not inhibit the N-terminal or C-terminal angiotensin converting enzyme active sites in humans.

Grégoire G Wuerzner, Séverine S Peyrard, Anne A Blanchard, Florent F Lalanne, and Michel M Azizi

J Hypertens 27(7):1404-9 (2009) PMID 19506528

The potential blood pressure lowering effect of fermented milk may involve inhibition of angiotensin-converting enzyme (ACE) by dairy lactotripeptides generated during milk fermentation, such as isoleucine-proline-proline (IPP) and valine-proline-proline (VPP). These peptides are weak ACE inhibitors in vitro but it remains unclear whether they inhibit ACE in vivo in humans.

DOI: 10.1097/HJH.0b013e32832b4759
Version: za2963e q8zab q8zb5 q8zc9 q8zd2 q8zeb q8zf3 q8zg7
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