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Benzothiazines in synthesis. A formal total synthesis of pseudopteroxazole.

Michael M Harmata, Zhengxin Z Cai, and Yugang Y Chen

J Org Chem 74(15):5559-61 (2009) PMID 19537725 PMCID PMC2821684

A formal total synthesis of the antitubercular natural product was accomplished. This work was undertaken to address certain stereochemical problems in our initial synthesis. By using an ester group as a surrogate for a methyl group, we were able to intercept a key intermediate in our first synthesis with better selectivity and greater convergence than had previously been the case.

DOI: 10.1021/jo9009112
Version: za2963e q8zaa q8zb2 q8zc1 q8zd1 q8zef q8zf0 q8zgb
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