Halophilic bacteria strain Halomonas salina DSM 5928 was found to excrete ectoine, suggesting its potential in the development of a new method of ectoine production. We performed HPLC and LC-MS analyses that showed that Halomonas salina DSM 5928 excreted ectoine under constant extracellular osmolarity. Medium adopting monosodium glutamate as a sole source of carbon and nitrogen was beneficial for ectoine synthesis. The total concentration of ectoine was not affected by NaCl concentration in the range 0.5-2 mol l(-1). The total concentration of ectoine and productivity in a 10-l fermentor with 0.5 mol l(-1) NaCl were 6.9 g l(-1) and 7.9 g l(-1) d(-1), respectively. These findings show that Halomonas salina DSM 5928 efficiently produces ectoine at relatively low NaCl concentration. This research also indicates the potential application of free or immobilized cells for continuous culture to produce ectoine.
Cisplatin is one of the most potent chemotherapeutic antitumor drugs used in the treatment of a wide range of solid tumors. Its primary dose-limiting side effect is nephrotoxicity. The organic anion transporter 5 (Oat5) is exclusively localized in the kidney. Oat5 urinary excretion w...
Plasmonic color filters employing a single optically-thick nanostructured
metal layer have recently generated considerable interest as an alternative to
colorant-based color filtering technologies, due to their reliability, ease of
fabrication, high color tunability. However, their relatively low t...
We address the metric reconstruction problem of such filamentary
Structures from data sampled around them. We prove that they can be
Approximated, with respect to the Gromov-Hausdorff distance by well-chosen Reeb
Graphs (and some of their variants) and we provide an efficient and easy to
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