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Production and optimization of valproic acid nanostructured lipid carriers by the Taguchi design.

Jaleh Varshosaz, Sharareh Eskandari, and Majid Tabakhian

Pharm Dev Technol 15(1):89-96 (2010) PMID 19552542

The objective of this study was production of nanostructured lipid carriers (NLC) of valproic acid for brain delivery thought the nasal pathway. NLC were prepared by solvent diffusion method using a Taguchi design. The lipid, oil and valproic acid were dissolved in organic phase then dispersed in aqueous phase containing the surfactant. The most effective factors on size were surfactant concentration, organic/aqueous phase ratio and acetone/ethanol volume ratio. Zeta potential was more affected by the lipid type, while the surfactant concentration and sonication time were more effective variables on drug release rate. The entrapment efficiency was more affected by lipid/drug weight ratio. Optimum formulation obtained with 400 mg lipid, 400 mg valproic acid, 2% surfactant, 1:5 organic/aqueous phase ratio, 1:1 acetone/ethanol volume ratio and 2 min sonication.

DOI: 10.1080/10837450903013568
Version: za2963e q8za4 q8zb2 q8zc3 q8zd4 q8zea q8zfe q8zge

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