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ICAM-5 modulates cytokine/chemokine production in the CNS during the course of herpes simplex virus type 1 infection

Margaret CL Tse, Crystal Lane, Kevin Mott, Nattawat Onlamoon, Hui-Mien Hsiao, and Guey Chuen Perng

J Neuroimmunol 213(1-2):12-19 (2009) PMID 19589604 PMCID PMC2750088

Chemokines are important in HSE development in the CNS but underlying regulatory events are unknown. Two-hybrid binding assays identified that intercellular adhesion molecule 5 (ICAM-5), an immune modulator in the CNS, interacted with neurovirulence factor, UOL, of HSV-1. Viral load and interleukin levels were similar in UOL deletion virus (@DUOL), and wild type virus infected mouse brains. However, higher numbers of lymphocytes, but unaltered soluble ICAM-5 and chemokine levels were detected in @DUOL infected mouse brains. In contrast, lower lymphocyte numbers, reduced soluble ICAM-5, and higher chemokine levels were detected in wild type virus infected brains. Our results suggest that ICAM-5 plays a critical role in modulating chemokine production in the CNS.

Copyright © 2009 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.jneuroim.2009.06.007
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