Advanced search×

Cognitive/personality pattern and triplet expansion size in adult myotonic dystrophy type 1 (DM1): CTG repeats, cognition and personality in DM1.

A Sistiaga, I Urreta, M Jodar, A M Cobo, J Emparanza, D Otaegui, J J Poza, J J Merino, H Imaz, J F Martí-Massó, and A López de Munain

Psychol Med 40(3):487-95 (2010) PMID 19627641

Although central nervous system (CNS) involvement in adult myotonic dystrophy type 1 (DM1) was described long ago, the large number of variables affecting the cognitive and personality profile have made it difficult to determine the effect of DM1 on the brain. The aim of this study was to define the cognitive and personality patterns in adult DM1 patients, and to analyse the relationship between these clinical patterns and their association with the underlying molecular defect.

DOI: 10.1017/S0033291709990602
Version: za2963e q8zaf q8zb7 q8zc9 q8zd6 q8ze8 q8zfe q8zg3

Similar articles you may find interesting…

  1. Long-term response to highly active antiretroviral therapy with lopinavir/ritonavir in pre-treated vertically HIV-infected children.
    Beatriz B Larrú, Salvador S Resino, ... M Angeles MA Muñoz-Fernández

    J Antimicrob Chemother 61(1):183-90 (2008) PMID 18025025

    Our study demonstrates ongoing immune recovery among children on HAART with lopinavir/ritonavir after 4 years of follow-up. Lopinavir/ritonavir, when given as part of a salvage regimen, is safe and well tolerated in HIV-infected children....
  2. Nuclear factor-kappaB activation regulates cyclooxygenase-2 induction in human astrocytes in response to CXCL12: role in neuronal toxicity.
    Susana Alvarez, Almudena Blanco, ... M Ángeles Muñoz-Fernández

    J Neurochem 113(3):772-83 (2010) PMID 20180883

    We have investigated the relationship between CXCL12, cyclooxygenase-2 (COX-2) and PGE(2) in human brain cells. CXCL12 induced COX-2 and secretion of PGE(2) in a dose-dependent manner in human astrocytes. This induction was abolished by treatment with PTx and AMD3100, confirming the role of CXCR4 si...
  3. Immunological recovery and metabolic disorders in severe immunodeficiency HIV type 1-infected children on highly active antiretroviral thera...
    Salvador Resino, Dariela Micheloud, ... Spanish Group of Paediatric HIV Infection

    AIDS Res Hum Retroviruses 24(12):1477-84 (2008) PMID 19018671

    We included 55 children who were stratified into three groups according to %CD4(+) pre-HAART and rate of immunologic recovery: (1) S1-Rec: CD4(+) < or =5% at baseline and slow immunologic recovery; (2) S2-Rec: CD4(+) 5-15% at baseline and slow immunologic recovery; (3) R-Rec: CD4(+) < or =15% at bas...