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An integrated microfluidic device for large-scale in situ click chemistry screening.

Yanju Y Wang, Wei-Yu WY Lin, Kan K Liu, Rachel J RJ Lin, Matthias M Selke, Hartmuth C HC Kolb, Nangang N Zhang, Xing-Zhong XZ Zhao, Michael E ME Phelps, Clifton K F CK Shen, Kym F KF Faull, and Hsian-Rong HR Tseng

Lab Chip 9(16):2281-5 (2009) PMID 19636457

An integrated microfluidic device has been developed to perform 1024 in situ click chemistry reactions in parallel using the bovine carbonic anhydrous II (bCAII) click chemistry system as a proof-of-concept study and a rapid hit identification approach using SPE purification and electrospray-ionization mass spectrometry, multiple reaction monitoring (MRM) analysis, all of which improves the sensitivity and throughput of the downstream analysis.

DOI: 10.1039/b907430a
Version: za2963e q8za0 q8zbb q8zcb q8zd3 q8ze8 q8zf1 q8zg4
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