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MEK4 function, genistein treatment, and invasion of human prostate cancer cells.

Li L Xu, Yongzeng Y Ding, William J WJ Catalona, Ximing J XJ Yang, Wayne F WF Anderson, Borko B Jovanovic, Kenji K Wellman, Jaqueline J Killmer, Xiaoke X Huang, Karl A KA Scheidt, R Bruce RB Montgomery, and Raymond C RC Bergan

J Natl Cancer Inst 101(16):1141-55 (2009) PMID 19638505

Dietary intake of genistein by patients with prostate cancer has been associated with decreased metastasis and mortality. Genistein blocks activation of p38 mitogen-activated protein kinase and thus inhibits matrix metalloproteinase-2 (MMP-2) expression and cell invasion in cultured cells and inhibits metastasis of human prostate cancer cells in mice. We investigated the target for genistein in prostate cancer cells.

DOI: 10.1093/jnci/djp227
Version: za2963e q8zac q8zb0 q8zcf q8zdc q8ze8 q8zf9 q8zg1
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