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HIV type-1 entry inhibitors with a new mode of action.

Ryan C Fink, Bill Roschek, and Randall S Alberte

Antivir Chem Chemother 19(6):243-55 (2009) PMID 19641233

The development of antiviral drugs has provided crucial new means to mitigate or relieve the debilitating effects of many viral pathogens. Regular use of these drugs has led to generation of resistant strains, making the control of many viral infections very difficult, particularly in HIV-seropositive and AIDS patients. A rich source for the discovery of new HIV infection inhibitors has been, and continues to be, the 'mining' of the large diversity of compounds already available in nature, and specifically those from botanical extracts.

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