Use of phage display to isolate specific human monoclonal antibody fragments against a potential target for multiple myeloma.

Ann Acad Med Singapore 38(7):621-9 (2009) PMID 19652854

Multiple myeloma (MM), a malignancy of plasma cells, accounts for 10% of all haematological malignancies and is currently incurable. Although it can be treated, the disease tends to relapse after several years and becomes increasingly resistant to conventional therapy. Investigations into using humoral therapy for MM are now underway with a view that novel therapeutic agents may provide a more targeted therapy for MM.